Evaluating left ventricular function in congestive heart failure before and after treatment assessed by Doppler tissue imaging

Objective:To analyse the correlation of parameters between left ventricular systolic function,functional class,and the systolic and diastolic function of left ventricle before and after treatment by Doppler tissue imaging(DTI).Methods:Thirty-four consecutive patients with a clinical diagnosis of congestive heart failure were studied by DTI.Four sites at mitral annuli were selected corresponding to the septal,lateral,anterior and inferior walls of the ventrical from apical 4-and 2-chamber views.We detected wall motion of mitral valve annulus and recorded DTI indexes included the peak systolic velocities(Sa),the peak early and late diastolic velocities(Ea and Aa).Sa/Ea and VMS were calculated.Thirty-four normal subjects were selected as control group.Results:Sa derived from the lateral site of mitral annulus from apical four-chamber view correlated well with functional class(rs=-0.65,P0.0001),the 4-site average velocities of mitral annulus correlated better with functional class(rs=-0.69,P0.0001).Compared with healthy controls,Sa and Ea of all 4 sites were significantly decreased(P0.001),Ea/Sa significantly increased(P0.01).After treatment,Sa and Ea of all 4 sites were significantly increased(P0.001),Ea/Sa significantly decreased(P0.01).Conclusions:Left ventricular systolic and diastolic function could be quantitatively analyzed by DTI,there are more close correlation between the 4-site average velocities of mitral annulus VMS and NYHA functional class.