Effects of atorvastatin and simvastatin on ventricular arrhythmias induced by ischemia-reperfusion in rabbit heart wedge

Objective To evaluate the effect of atorvastatin and simvastatin on electro physiological parametes and ventricular arrhythmias induced by ischemia reperfusion in rabbit heart′s wedge.Methods Thirty-six rabbits were randomly divided into control,ischemia reperfusion,atorvastatin and simvastatin groups.Each group consisted of 9 rabbits.Arterially perfused rabbit′s left ventricular models were made by standard method,and transmural ECG as well as action potentials from both endocardium and epicardium were simultaneously recorded.QT interval,transmural dispersion of repolarization(TDR),action potentials from epicardium and endocardium and incidence of ventricular arrhythmia were recorded after the condition of ischemia for 30 min and reperfusion with 15 min.Results Compared with control group,the QT interval,action potential duration 90%(APD90) of epimembrane and endomembrane were significantly reduced in ischemia and reperfusion group(all P﹤0.05).The electrophysiological parametes were increased in reperfused condition compared to ischemia condition,especially the Tp-e/QT was changed(P﹤0.01).The electrophysiological parametes were not changed in atorvastatin and simvastatin groups,compared with schemia and reperfusion group(all P0.05).Ventricular arrhythmia was not observed in control group.However,ventricular arrhythmias were induced in other groups,under the condition of ischemia there were no significant difference,but in perfusion station the incidence of ventricular arrhythmias were reduced in atorvastatin and simvastatin groups compared with ischemia and perfusion group(0,1/9 vs 5/9,P﹤0.01).Conclusion The incidence of ventricular arrhythmia due to ischemia-reperfusion can be reduced by perfusing with atorvastin and simvastatin.