Relationship Between Plasma Level of NT-proBNP and Ventricular Diastolic Dysfunction in Elder Hypertensive Patients Without Target Organ Damage

Objective: To study the relationship between plasma level of N-terminal B-type natriuretic peptide(NT-proBNP) and ventricular diastolic dysfunction in elder hypertensive patients without target organ damage. Methods: A total of 66 relevant patients treated in our hospital from 2012-03 to 2014-03 were studied. According to the standard of ventricular diastolic dysfunction, the patients were divided into 2 groups: Study group, n =27 patients with diastolic dysfunction and Control group, n =39 patients without diastolic dysfunction. The patients in Study group were further divided into 3 sub-groups based on Doppler classification of diastolic dysfunction: Grade 1, the patients with E/A 1.0, DT ≥ 240 ms, IVRT 90 ms, n=8. Grade 2, the patients with E/A 1.5, DT(150-220) ms, IVRT 90 ms, n =13. Grade 3-4, the patients with E/A 1.5, DT ≤ 150 ms, IVRT 70 ms, n =6. Plasma levels of NT-pro BNP and Doppler ultrasound findings were compared to study the relationship between NT-proBNP and ventricular diastolic dysfunction. Results: Plasma level of NT-pro BNP was higher in Study group than that in Control group. NT-pro BNP level in Grade 3-4 sub-group was obviously higher than those in Grade 1 and Grade 2 sub-groups, NT-proBNP level in Grade 2 sub-group was higher than that in Grade 1 sub-group. Pearson correlation analysis indicated that NT-pro BNP level was positively related to systolic blood pressure, diastolic function and E/E'(r=0.211, P=0.037, r=0.442, P=0.004 and r=0.556, P=0.000), while negatively related to E'/A'(r=-0.372, P =0.000). Conclusion: The increased plasma level of NT-proBNP are highly support for ventricular diastolic dysfunction in elder hypertensive patients without target organ damage, NT-proBNP level is related to ventricular diastolic function.