Analysis on cilincal pathological data of 59 cases of lupus nephritis

Objective: To survey the epidemiology,pathological category and clinical manifestation of lupus nephritis(LN) and to investigate the interrelationship between clinical features and pathological category.Methods: The clinicopathological data of 59 cases diagnosed as LN undergoing renal biopsy were obtained.The patients came from Department of Nephropathy,the Affiliated Zhongda Hospital to Southeast University from October 2003 to December 2009.The distribution of clinical features,the distribution of pathological patterns,the interrelationship between clinical features,pathological patterns and immunne index were analyzed.Results: There were 8 males and 51 females,and the ratio of male to female was 1∶6.3.The mean age of the male patients was(28.6±10.6) years old and female patients was(37.3±10.3) years old.In the 59 cases,type Ⅳ LN was the most frequent type(55.9%),followed by type Ⅲ(11.9%),Ⅴ(10.2%),Ⅱ(8.4%),Ⅳ plus Ⅴ(8.4%) and Ⅲ plus Ⅴ(5.1%) of LN.The patients clinically manifesting latent glomerulonephritis or nephritic syndrome were mainly type II or Ⅲ of LN,nephrotic syndrome were mostly type Ⅳ,Ⅴ,Ⅳ plus Ⅴ or Ⅲ plus Ⅴ of LN.Cases with clinical diagnose of renal failure were mainly type Ⅳor Ⅳ plusⅤ of LN,which had a significance compared with oter types of LN(P0.05).The patients of type Ⅳ of LN were mainly hematuria.It was the most frequency of anemia in type Ⅳ or Ⅳ plusⅤ of LN than in other types of LN(P0.05).The prevalence of hypertension was significantly increased in types Ⅳ,Ⅴor Ⅳ plus Ⅴ of LN than types Ⅱ and Ⅲ of LN(P0.05).Active index of type Ⅳ of LN was mostly higher than other types of LN(P0.05).Among immune index,the decreased levels of complement C3,higher levels of anti-dsDNA and anti-nuclear antibody in serum were mostly observed.Furthermore,the level of complement C3 in type IV of LN was significantly decreased than other types of LN(P0.05).Conclusion: The results suggest there exists a corresponding relationship between the pathological patterns and clinical manifestations of LN.Based on the clinical data of LN,speculation of the pathological pattern of LN can be drawn,which helps a lot in the hospitals where renal biopsy technique has not developed.