Expression of Glucose Transporter 1 and Glucose Transporter 3 in Non-small Cell Lung Cancer and Its Clinical Significance

Objective To investigate the expressions of glucose transporter(GLUT) 1 and GLUT3 in lung cancer and benign pulmonary lesions and their relations during the occurrence and development of lung cancer. Methods Tissues of 68 non-small cell lung cancer(NSCLC) and 17 benign pulmonary lesions were collected,and then stained by monoclonal antibodies of GLUT1 andGLUT3 mediated ABc immunohistochemical method.Results The GLUT1 positive rate of lung cancer tissues was 85.3%(58 out of 68),which significantly correlated with cell differentiation degree,TNM stage and lymph node metastasis.Concretely,the GLUT1 positive rates of squamous cell carcinoma and adenocarcinoma were 100.0% and 75.5% respectively.18 of 68 lung cancer tissues were GLUT3 positive,and the positive rates of squamous cell carcinoma and adenocarcinoma were 41.2% and 11.8% respectively,which had no significant correlations with cell differentiation degree,TNM stage and lymph node metastasis.All GLUT3 positive samples were also GLUT1 positive.The expressions of GLUT1 and GLUT3 had not been detected in benign pulmonary lesions.Conclusions GLUT1 over-expression exists in NSCLC,which is closely related with TNM stages,lymph node metastasis and cell differentiation degree and involved in the occurrence and development of lung cancer.Over-expression of GLUT3 exists in a few of NSCLC,usually after the over-expression of GLUT1.