Pharmacokinetics of Alkaline Norfloxacin Injected in Healthy Swine

Alkaline norfloxacin was given to health swine at a dosage of 10 mg/kg of body weight im and iv in a complete crossover study.Norfloxacin concentration in plasma was assayed by a high performance liquid chromatography(HPLC) method using an UV detector.All the data were processed by MCPKP computer software and the pharmacokinetics parameters were calculated,based on two-compartment open model.The results revealed that the parameters of alkaline norfloxacin after single im dose:the maximal concentration(C_(max)) was ((2.630 80)±(0.683 06)) mg/L,the elimination half life (T_(1/2),β) was ((6.075 17)±(3.047 61)) h,the area under curve (AUC) was (12.499±2.423) mg/L·h,the bioavailability(F) was 48.4%. The parameters of alkaline norfloxacin after single iv dose:the C0 was ((12.736 48)±(5.183 52)) mg/L,the elimination half life (T_(1/2),β) was ((3.312 89)±(0.484 39)) h,the area under curve (AUC) was (25.747±3.149) mg/L·h.