Study on the relationship between polymorphism of PTPN22 and Graves'disease of Han nationality in Chongqing area

Objective:To investigate the relationship between the polymorphism of PTPN22 gene exon14 C1858T and Graves' disease(GD)in Han Group in Chongqing area.Methods:The PTPN22 gene C1858T alleles were typed by polymerase chain reaction based restriction fragment length polymorphism(PCR-RFLP)method in 283 GD patients and 218 normal subjects.The comparisons of genotype and allele frequencies were made between GD patients and normal group.Results:The frequencies of CC、CT and TT genotype in GD patients and normal group were 97.2%,2.8%,0% respectively,Their χ2 were 0.139 and 0.002 respectively,and p were 0.71 and 0.96 respectively.There was no significant difference of the genotypes and allele frequencies at position-1858 of PTPN22 in GD patients compared with those of normal group,and there was no TT genotype and a few T alleles.Conclusion:There is no correlation between the polymorphism of PTPN22 gene exon14 C1858T and GD patients in Han nationality of Chongqing.