Hemodynamic Changes of Proximal and Distal Artery of Serious Stenosis or Occlusion of Internal Carotid Artery

[Objective] To explore the hemodynamic changes of proximal and distal artery of serious stenosis or occlusion of internal carotid artery.[Methods]One hundred and twenty-one patients with serious stenosis or occlusion of internal carotid artery determined by digital subtraction or MR angiography were selected to serve as patient group and eighty patients without disease of internal carotid artery were selected to serve as controls.All patients were measured by transcranial Doppler(TCD).[Results]In proximal common carotid artery,TCD showed abnormal flow waveforms that manifested narrow systolic peak,diastolic flow velocity decrease or disappearance and early diastolic flow diversion.The blood flow velocity of common carotid artery was lower than controls,but its pulsitility index was significantly higher than controls(P0.01).In distal middle cerebral artery,TCD showed abnormal flow waveforms that manifested blunt systolic peak,diastolic flow velocity acceleration.The blood flow velocity and pulsitility index of middle cerebral artery were significantly lower than controls(P0.01).[Conclusion]TCD may further help to know the hemodynamic changes of proximal and distal artery of serious stenosis or occlusion of internal carotid artery.TCD may be important and objective index in the diagnosis and pathogenesis of ischemic cerebrovascular disease.