Efficacy of acarbose and metformin in treatment of type 2 diabetes

Objective To observe the effect acarbose and metformin in treatment of type 2 diabetes. Methods Sixty-four cases of type 2 diabetes patients were treated strictly controlled diet,exercise,on the basis of each group to metformin0.5 g,orally,3 times / d,observation group were treated with acarbose 50 mg,3 times / d,lunch and dinner orally,if blood glucose control was not satisfactory,gradually increased dose to 100 mg/times,for 12 weeks.The efficacy of the two groups were compared. Results The fasting blood glucose were observed before the treatment group and the control group of patients and 2 h postprandial blood glucose compared with no significant difference(P 0.05), lower than before treatment and after treatment,fasting blood glucose and meal after 2 h plasma glucose was(8.3±1.6) mmol/L,(10.2±1.5) mmol/L,respectively,significantly lower than the control group(P0.05). After 12 weeks of treatment,the total curative rate was 93.8%(30/32) in the observation group, the total efficacy rate of the control group was 71.9%(23/32),the difference was significant group between the two groups(χ2=6.387,P0.05). Conclusion Acarbose and metformin in treatment of type 2 diabetes can significantly improve the efficacy,control blood sugar levels,safety,worthy of promotion and application.