Research the Relation of Hepatic Fibrosis with Serum NO in Patients with Chronic Hepatitis B

Objective: To discuss the changes of serum nitric(NO),hyalopasm acid(HA),laminin(LN)and collagen type IV(C-IV) level on hepatic fibrosis mechanism by studying them in patients with chronic hepatitis B(CHB).Method: The concentrations of serum NO,HA,LN,C-IV in 107 patients with CHB and 20 healthy adult were measured by colorimetry and radioimmunoassay.Result: The levels of serum NO in mild CHB group moderate CHB group,severe CHB group and liver cirrhosis(LC) group were higher significant than that in the control(p0.01),and change with the degree of hepatic injury and fibrosis,The level of serum NO was positive correlated with the levels of serum HA,LN and C-IV(p0.01).Conclusion: Serum NO is corresponding with not only hepatic injury,but also with hepatic fibrosis degree,NO takes,NO takes part in pathological process of viral hepatitis and hepatic fibrosis Testing the serum NO contributes to evaluating the hepatic fibrosis degree in patients with chronic hepatic disease