The effect of sevoflurane-remifentanil on neuromuscular blocking effect of cisatracurium in elderly

Objective This study was designed to compare the effect of sevoflurane and remifentanil on neuromuscular blocking effect of cisatracurium in elderly and adult. Methods 40 patients,ASA Ⅰ- Ⅱ,undergoing elective surgery, were randomly divided into elderly and adult groups. Anesthesia was induced with sevoflurane 8% using a vital capacity breath technique,after BIS value acheieved 60,remifentanil 2- 4 ng / ml was given,cisatracurium 0. l5 mg / kg were administered after induction. Anaesthesia was maintained with end-tidal concentrations 1. 0 MAC and remifentanil( 2 ng / ml). Cumulative dose-effect curves for cisatracurium were determined during anaesthesia with 1. 73% sevoflurane. Neuromuscular block was assessed by acceleromyography( TOF-Watch) after train-of-four( TOF) stimulation of the ulnar nerve. Results There was no significant difference between the two groups( P 0. 05). And The duration of recovery to 25%, 75% of T1( T1 25%,T1 75%),TOF rate of 0. 9,recovery index( RI) was no significantly different between the two groups( P 0. 05). Conclusion Aging had no influence on the pharmacodynamics of single injection of cisatracurium.