The clinical significance of total embryo frozen in in vitro fertilization and embryo transplantation for patients with polycystic ovary syndrome/polycystic ovary

Objective To evaluate the clinical significance of total embryos frozen in in vitro fertilization and embryo transplantation(IVF-ET) for patients with the polycystic ovary syndrome/polycystic ovary(PCOS/PCO).Methods The clinical data of 206 IVF cycles under controlled ovarian hyperstimulation,including 157 fresh embryo transfer cycles(Group A),and 49 all frozen embryo transfer cycles(Group B),were retrospective analyzed.The clinical pregnancy outcomes were compared between the two groups.Logistic regression was used to analyze the factors related to the clinical pregnancy rate.Results Lower abortion rate,and higher implantation rate and clinical pregnancy rate were revealed in Group B than those in Group A;however,no significant differences was revealed.One case of moderate OHSS was recorded in Group A.According to univariate and multivariate analysis,the clinical pregnancy was significantly correlated with the number of high-quality embryo transferred.Conclusion PCOS/PCO patients with fresh embryo transfer and total frozen embryo transfer can achieve similar pregnancy outcomes,in which the key factor affecting the pregnancy rate is the number of high-quality embryos transferred.Total embryos frozen technique prevents the occurrence of moderate to severe OHSS,without adverse effects on clinical outcomes.