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The molecule mechanism of Hyperbaric Oxygen-treatment on brain cells apoptotic of in neonate rat with hypoxic-ischemic brain damage

Jianyong Jiang

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Abstract

Objective To explore the effect of Hyperbaric Oxygen(HBO) on the apoptosis resulted from Hypoxic-Ischemic Brain Damage(HIBD),and to observe the change of Caspase-3 and Caspase-9 expression in this process.Methods To observe the morphologic change of brain tissues treated by HBO,and compared with that of the Hypoxia-ischemia rat model,then check the change of Caspase-3 and Caspase-9 expression by immunohistochemistry at different time point.Results The expression of Caspase-3 and Caspase-9 in the cortex was higher than that of sham group at 18,24,48 and 96-hour time point.Compared with HIBD(P0.05).The increased rate of Caspase-3 and Caspase-9 expression was significantly decreased at each time point by HBO treatment(P0.05).Conclusion HBO decreased the apoptosis of cortex nerve cells on 7day-old HIBD rat model.

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Objective To explore the effect of Hyperbaric Oxygen(HBO) on the apoptosis resulted from Hypoxic-Ischemic Brain Damage(HIBD),and to observe the change of Caspase-3 and Caspase-9 expression in this process.Methods To observe the morphologic change of brain tissues treated by HBO,and compared with that of the Hypoxia-ischemia rat model,then check the change of Caspase-3 and Caspase-9 expression by immunohistochemistry at different time point.Results The expression of Caspase-3 and Caspase-9 in the cortex was higher than that of sham group at 18,24,48 and 96-hour time point.Compared with HIBD(P0.05).The increased rate of Caspase-3 and Caspase-9 expression was significantly decreased at each time point by HBO treatment(P0.05).Conclusion HBO decreased the apoptosis of cortex nerve cells on 7day-old HIBD rat model.

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Available abstract

Objective To explore the effect of Hyperbaric Oxygen(HBO) on the apoptosis resulted from Hypoxic-Ischemic Brain Damage(HIBD),and to observe the change of Caspase-3 and Caspase-9 expression in this process.Methods To observe the morphologic change of brain tissues treated by HBO,and compared with that of the Hypoxia-ischemia rat model,then check the change of Caspase-3 and Caspase-9 expression by immunohistochemistry at different time point.Results The expression of Caspase-3 and Caspase-9 in the cortex was higher than that of sham group at 18,24,48 and 96-hour time point.Compared with HIBD(P0.05).The increased rate of Caspase-3 and Caspase-9 expression was significantly decreased at each time point by HBO treatment(P0.05).Conclusion HBO decreased the apoptosis of cortex nerve cells on 7day-old HIBD rat model.

Key concepts: Apoptosis, Medicine, Hypoxia (environmental), Caspase 3, Immunohistochemistry, Ischemia, Brain damage, Cortex (anatomy)

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The molecule mechanism of Hyperbaric Oxygen-treatment on brain cells apoptotic of in neonate rat with hypoxic-ischemic brain damage — Research Paper | ScholarLens