Clinical effect of Compound Betamethasone and Triamcinolone Acetonide Acetate in treating alopecia areata by local injection

Objective To compare the clinical potency and untoward reactions of compound betamethasone and triamcinolone acetonide acetate in treating alopecia areata by local injection.Methods Totally 182 patients with alopecia areata were randomly divided into treatment group(n=91) and control group(n=91),using compound betamethasone(1ml and 2ml of 2%lidocaine,0.2ml/cm2)for treatment group by local injection,once per 4 weeks for 3 times directly.The control group were locally injected with triamcinolone acetonide acetate(1ml and 2ml of 2%lidocaine,0.2ml/cm2),once a week for 3 times directly,then observed the clinical potency and untoward reactions at 4th、8th、12th weeks respectively.All the patients were received VitaminB6 20 mg and oryzanol 20 mg,po,tid.Results At the 4th week,the effective power of treatment group and control group was 17.58% and 30.77%(P0.05),significant differences were found among the tow groups.At the 8th week,the effective power of the two groups was 46.15% and 53.85% respectively(P0.05).The treatment group's effective power(83.52%) was higher than that of control group(70.33%) at the 12th week(P0.05),remarkable differences were found.Conclusions The curative effect of local injecting glucocorticoid in treating alopecia areata was precisely.In early treatment triamcinolone acetonide acetate's effective power was better.But the effective power of compound betamethasone was exceed in long term observation.