Status and Advance in Treatment of HBV Infection with Lamivudine,Adefovir and Entecavir

Lamivudine,Adefovir and Entecavir can significantly inhibit the replication of HBV-DNA,reduce the HBV-DNA level in blood serum,normalize serum alanine aminotransferase (ALT),elevate the rates of hepatitis e antigen (HBeAg) seroconversion and HBeAg elimination,promote the improvement of the liver in histology,and with less side-effect and better tolerability.They play a pivotal role in treatment of hepatitis B.This review gives a comparison and overview of recent findings and developments of these three types of nucleoside analogs in (1) treatment of adults,children and pregnant women with chronic hepatitis B,(2) treatment of hepatitis B-related cirrhosis,(3) prophylaxis and treatment of recurrent hepatitis B after liver transplantation,(4) resistance-associated mutation,and (5) common side-effects,with a purpose to promote a scientific and reasonable medication clinically.