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A Brief Review on ~(19)F NMR

Jianhua Zhang

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Abstract

Fluorine-19 (19F) isotope has 100% natural abundance, and the magnetic moment and relative NMR sensitivity of 19F nuclei are similar to those of 1H nuclei. The total range of 19F NMR chemical shifts is over δ 1 000, giving good spectral resolution. Compared to 1H NMR, 19F NMR is more sensitive to the changes in molecular structure and environmental factors, and thus can be used to probe fine structural difference of the compounds. In vivo 19F NMR spectroscopy provides a highly specific tool for identifying the existence of fluorine-containing drugs and their metabolites in the tissue. In this paper, the 19F chemical shifts and coupling constants of various fluorine-containing compounds were summarized and reviewed.

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What this paper is about

Fluorine-19 (19F) isotope has 100% natural abundance, and the magnetic moment and relative NMR sensitivity of 19F nuclei are similar to those of 1H nuclei. The total range of 19F NMR chemical shifts is over δ 1 000, giving good spectral resolution. Compared to 1H NMR, 19F NMR is more sensitive to the changes in molecular structure and environmental factors, and thus can be used to probe fine structural difference of the compounds. In vivo 19F NMR spectroscopy provides a highly specific tool for identifying the existence of fluorine-containing drugs and their metabolites in the tissue. In this paper, the 19F chemical shifts and coupling constants of various fluorine-containing compounds were summarized and reviewed.

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Available abstract

Fluorine-19 (19F) isotope has 100% natural abundance, and the magnetic moment and relative NMR sensitivity of 19F nuclei are similar to those of 1H nuclei. The total range of 19F NMR chemical shifts is over δ 1 000, giving good spectral resolution. Compared to 1H NMR, 19F NMR is more sensitive to the changes in molecular structure and environmental factors, and thus can be used to probe fine structural difference of the compounds. In vivo 19F NMR spectroscopy provides a highly specific tool for identifying the existence of fluorine-containing drugs and their metabolites in the tissue. In this paper, the 19F chemical shifts and coupling constants of various fluorine-containing compounds were summarized and reviewed.

Key concepts: Fluorine-19 NMR, Chemistry, Chemical shift, Nuclear magnetic resonance spectroscopy, Nuclear magnetic resonance spectroscopy of nucleic acids, Fluorine, Carbon-13 NMR satellite, Natural abundance

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