Study of the effects of early enteral nutrition on the inflammatory response after shock

Objective To study the therapeutic effects of early enteral nutrition on the serum endotoxin,tumor necrosis fator-α(TNF-α) and systemic inflammatory response syndrome(SIRS) of patients after shock.Methods Sixty-seven patients were randomly divided into early enteral nutrition group and total parenteral nutrition(TPN) group after shock.The serum endotoxin and TNF-α level were detected at 0 d,1 d,3 d and 5 d respectively.The duration of SIRS and the morbidity rates of multiple organ dysfunction syndrome(MODS) were compared between two groups.Results The serum endotoxin and TNF-α level of patients suffered from shock in EN group were obviously lower than those in TPN group after 5 days(P0.01).The duration of SIRS and the morbidity rates of MODS in EN group were lower than those in TPN group(P0.05).Conclusion Early enteral nutrition can decrease the serum endotoxin and TNF-α level in shock patients,which is redound to attenuate the SIRS and decrease morbidity the rate of MODS.