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2006•Zhonghua neifenmi daixie zazhiRequires access

Influence of islet 11β-HSD1 expression on isletβ-cell function in streptozotocin and high-fat induced diabetic rats

YU Yi-kai

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Abstract

Intraperitoneal glucose tolerance test was performed in the streptozotocin- and high fat-induced diabetic rats and normal rats.The results of RT-PCR and Western blot showed that the expression of 11β- hydroxysleroid dehydrogenase type 1 (11β-HSD1) was higher in the diabetic rats than that in control and was correlated with fasting plasma glucose,insulin and AUC-I/G with respective correlation coefficient (r) of 0.870, - 0.799,- 0.850,suggesting that increased expression of 11β-HSD1 appears to damageβ-cell function through magnifying the local effect of glucocorticoids.

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What this paper is about

Intraperitoneal glucose tolerance test was performed in the streptozotocin- and high fat-induced diabetic rats and normal rats.The results of RT-PCR and Western blot showed that the expression of 11β- hydroxysleroid dehydrogenase type 1 (11β-HSD1) was higher in the diabetic rats than that in control and was correlated with fasting plasma glucose,insulin and AUC-I/G with respective correlation coefficient (r) of 0.870, - 0.799,- 0.850,suggesting that increased expression of 11β-HSD1 appears to damageβ-cell function through magnifying the local effect of glucocorticoids.

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Available abstract

Intraperitoneal glucose tolerance test was performed in the streptozotocin- and high fat-induced diabetic rats and normal rats.The results of RT-PCR and Western blot showed that the expression of 11β- hydroxysleroid dehydrogenase type 1 (11β-HSD1) was higher in the diabetic rats than that in control and was correlated with fasting plasma glucose,insulin and AUC-I/G with respective correlation coefficient (r) of 0.870, - 0.799,- 0.850,suggesting that increased expression of 11β-HSD1 appears to damageβ-cell function through magnifying the local effect of glucocorticoids.

Key concepts: Internal medicine, Endocrinology, Streptozotocin, Islet, Diabetes mellitus, Intraperitoneal injection, Western blot, Insulin

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Influence of islet 11β-HSD1 expression on isletβ-cell function in streptozotocin and high-fat induced diabetic rats — Research Paper | ScholarLens