2008•Chinese Journal of Cardiovascular MedicineRequires access
Effect of atorvastatin on angiotensinII and hemo oxygenase-1 expression in the brains of hypercholesterolemic rabbit
LU Yu-sa
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Abstract
Objective To establish model of rabbit with hypercholesterolemia and investigate the influence of Atorvastatin on the expression of angiotensinⅡ(AngⅡ) and hemo oxygenase-1(HO-1) in rabbit brain tissue. Methods Twenty-four healthy New-Zealand albino rabbits were divided into 3 groups randomly: normal control,high cholesterol diet,high cholesterol diet and Atorvastatin.After feeding for 8 weeks,fasting blood samples were collected and total cholesterol(TC)and low density lipoprotein cholesterol(LDL-C) levels were determined.Rabbit brains were extracted after sacrifice and expressions of AngⅡand HO-1 were assayed. Results AngⅡ expression in high cholesterol diet group was higher than in control group(P0.05);AngⅡ expression in Atorvastatin group was lower than in high cholesterol diet group(P0.05).HO-1 expression in high cholesterol diet group was higher than in control group(P0.05);HO-1 expression in Atorvastatin group was higher than in high cholesterol diet group(P0.05). Conclusions Rennin-angiotensin-aldosterone system(RAAS) in brain tissue is activated under high cholesterol diet.Atorvastatin can prevent atherosclerosis by reducing AngⅡ production and increasing HO-1 expression.