Expressions of LYVE-1,CD31 in NSCLC and the Correlation with Neoplasm Metastasis

Objective To explore expression of LYVE-1,CD31 and its relationship with tumor metastasis in Non-Small Cell Lung Cancer(NSCLC).Methods LYVE-1 and CD31 were detected by EnVisionTM immunohistochmistry method in 40 tumour tissues and 40 adjacent tissues;the expression of LYVE-1 and CD31 was used to mark the lymphatic endothelial cell and vascular endothelial cell,the lymphatic vascular microvascular density(MLVD)and microvascular density(MVD).Results The MLVD of tumor tissues was different from normal lung tissues and adjacent tissues of NSCLC(P0.001);the MLVD of the lymph node metastasis was different from non-lymph node metastasis(P0.001);MLVD was different in Ⅲ+Ⅳ stage fromⅠ+Ⅱstage(P0.001);MLVD was not related with age,sex,tumor size,histological type and differentiation of NSCLC tumor tissues(P0.05).The MVD of tumor tissues was significantly higher than adjacent tissues(P0.001);The MVD of tumor tissues with lymph node metastasis was higher than those without lymph node metastasis,but the difference was statistically significant(P0.05);The MVD of tumor tissues in Ⅲ+Ⅳ stage was higher than those inⅠ+Ⅱstage,but the difference was not statistically significant(P0.05);There was no correlation between MLVD and MVD in tumor of NSCLC(P0.05).Conclusion LYVE-1 and CD31 may be used to estimate the progression and lymph node metastasis.