Expression and Significance of Tumor Stem Cancer Marker CD44~+CD24~(low/-) and MMP-9 in Breast Cancer

Objective To investigate the expression of Cancer Stem Cancer Marker CD44+CD24low/-and matrix metalloproteinase-9(MMP-9)in breast cancer and its relationship with the clinical characteristics of tumors.Methods In one hundred and nine cases of breast cancer tissues CD44,CD24 and MMP-9 were detected with immunohistochemisrty.Results(1)The expression rate of CD44,CD24 and MMP-9 protein was 47.7%、50.5% and 40.4% in 109 cases of breast cancer respectively.The expression rates of CD44 protein was related with breast cancer pathological grades(P0.05).(2)Thirty two positive cases of CD44+CD24low/-were detected in 109 cases of breast cancer.The expression of CD44+CD24low/-was closely related with breast cancer pathologic grades.(3)The expression of MMP-9 protein was in inverse correlations with lymphoid metastasis in CD44+CD24low/-positive cases(P0.05).Conclusion CD44+CD24low/-TSC is often be found in poor differentiation breast cancer tissues.And MMP-9 protein can be an important factor in invasion of CD44+CD24low/-TSC in early stage of breast cancer.