High frequency ventilation in treatment of infants with severe respiratory failure

Objective To evluate the effectiveness of high frequcncy ventilation (HFV) in treatment of infants with severe respiratory failure.Methods 37 neonates with severe respiratory failure were changed by HFV because FiO2≥0.8,MAP≥10 cmH2O,TcSO2≤90% lasted more than 2 hours during the conventional mechnaical ventilation (CMV) or chest X-ray showed pneumothorax or continuous hypercapnia We recorded parameter;FiO2、a/A、OI、MAP、PIP and amplitude.Results 22 patients were treated successfully with HFV,15 patients failured.The treatment-success group:After the patients were treated with HFV for 12 h,FiO2 was declined (P0.05),a/A was arised (P0.05),OI was obviously descended(P0.01).The treatment-failured group:After the patients were treated with HFV for 12 hours,FiO2 was not changed apparently,a/A was not increased,OI had no good trend after 6 hours.It had no significant difference,although OI was decreased after 12 hours.Conclusion Infants with severe respiratory failure in whom CMV failed,HFV is a valid alternative method.