Antinuclear antibody detection in the clinical diagnosis of diffuse connective tissue disease

Objective To evaluate the clinical diagnosis of diffuse connective tissue disease patients by antinuclear antibody test results. Method Methods a retrospective analysis of 246 cases of diffuse connective tissue diseases and 160 cases of non diffuse connective tissue disease detection in hospitalized patients with autoantibody. Result In a variety of diffuse connective tissue disease antinuclear antibody positive rate between the difference has statistical significance, in systemic lupus erythematosus patients, the positive rate of anti ds DNA antibody was 44.1%, the positive rate of anti Sm antibody positive rate was 47%; in mixed connective tissue disease in anti UIRNP antibody was 96.4% in patients with Sjogren syndrome; syndrome of anti SSA and anti SSB antibody positive rate was 68.2% and 59.1%; in patients with systemic sclerosis in anti Scl- 70 antibody positive rate was 41.4%; overlap syndrome, anti ds DNA, anti Sm, anti UIRNP, anti SSA antibody positive rate was 45.4%, 18.2%, 45.4%,18.2%. Conclusion There are important in the differential diagnosis of antinuclear antibody spectrum detection of diffuse connective tissue disease.