Therapeutic effect of captopril combined with rosiglitazone on early diabetic nephropathy

Objective To observe the therapeutic effect of captopril combined with rosiglitazone on early diabetic nephropathy.Methods 60 patients with early diabetic nephropathy were randomly divided into treatment group and control group.On the basis of controlling blood sugar,30 patients in control group were treated by captopril 25mg once,three times a day,while the other 30 patients in treatment group,on the basis of the control group,were treated by rosiglitazone 4 mg daily for oral dose,with a treatment course of 3 months for both groups.The fasting plasma glucose(FPG),total cholesterol(TC),triglycerides(TG),high-density lipoprotein-cholesterol(HDL-C),low density lipoprotein-cholesterol(LDL-C),urinary albumin(ALB),systolic blood pressure(SBP),diastolic blood pressure(DBP)were detected before and after treatment for both groups.Results After treatment the urinary ALB and FPG in treatment group were decreased significantly,as compared with those of control group(P0.05),however,there was no significant difference in TC,TG,HDL-C,LDL-C,SBP and DBP between two groups(P0.05).Conclusion The captopril combined rosiglitazone has a protective effect on early diabetic nephropathy,which can reduce the urinary excretion of albumin more effectively in patients with early diabetic nephropathy.