The Analysis of The Effect and Security of Buspirone Combined with Paroxetine in Treating Anxiety

Objective: To study the effect and security of buspirone combined paroxetine in the treatment of anxiety. Methods:244 patients who were diagnosed with anxiety were chosen from 2009 January to 2013 Augst in our hospital, and were divided into treatment group(122 cases) and control group(122cases) randomly according to the principle of informed and consent, treatment group was treated with buspirone combined paroxetine, while the control group was treated with buspirone alone. after 10 weeks of treatment,Hamilton anxiety scale(HAMA) and Montgomery-Asberg depression scale(MADS) were used to evaluate the effect and treatment emergent symptom scale(TESS) was used to evaluate the security, the effect and security between two groups of patients was compared.Results: The score of HAMA and MADS of two groups after treatment were all lower than those before the treatment, and the scores of the treatment group were lower than the control group, the differences were all statistically significant(P0.05). There were no statistically differences in the comparison of the scores of TEES between two groups in the 2, 4, 6, 8, 10 weeks of treatment(P0.05). Conclusions:Buspirone combined paroxetine can improve the effect in treating anxiety and have high security, which could be considered to be widely applied in clinic.