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2008•Journal of psychiatryRequires access

A study of the efficacy and safety of ziprasidone in the treatment of schizophrenia

Song Aiping

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Abstract

Objective To explore the curative effect and security of ziprasidone for treating schizophrenia.Methods Sixty patients were chosen randomly and took ziprasidone in a dosage of 80-120mg per day for 6 weeks.The curative effect was estimated by PANSS and Clinical Global Impression Scale(CGI-SI),and the security was evaluated with TESS,physical and laboratory examination,ECG and describing records about other side effects.Results The scores of PANSS,positive symptoms,negative symptoms,general psychopathological symptoms and CGI-S decreased obviously.At the end of the trial,23 patients(38.33%)recovered,25(41.67%)improved notably,7(11.67%)improved.The excellence rate was 80.00%,and total effective rate was 91.67%.The rate of side effects was 46.67%.No severe side reactions occurred.Conclusion Ziprasidone could have good therapeutic effect and tolerance for treating patients with schizophrenia.

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What this paper is about

Objective To explore the curative effect and security of ziprasidone for treating schizophrenia.Methods Sixty patients were chosen randomly and took ziprasidone in a dosage of 80-120mg per day for 6 weeks.The curative effect was estimated by PANSS and Clinical Global Impression Scale(CGI-SI),and the security was evaluated with TESS,physical and laboratory examination,ECG and describing records about other side effects.Results The scores of PANSS,positive symptoms,negative symptoms,general psychopathological symptoms and CGI-S decreased obviously.At the end of the trial,23 patients(38.33%)recovered,25(41.67%)improved notably,7(11.67%)improved.The excellence rate was 80.00%,and total effective rate was 91.67%.The rate of side effects was 46.67%.No severe side reactions occurred.Conclusion Ziprasidone could have good therapeutic effect and tolerance for treating patients with schizophrenia.

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Available abstract

Objective To explore the curative effect and security of ziprasidone for treating schizophrenia.Methods Sixty patients were chosen randomly and took ziprasidone in a dosage of 80-120mg per day for 6 weeks.The curative effect was estimated by PANSS and Clinical Global Impression Scale(CGI-SI),and the security was evaluated with TESS,physical and laboratory examination,ECG and describing records about other side effects.Results The scores of PANSS,positive symptoms,negative symptoms,general psychopathological symptoms and CGI-S decreased obviously.At the end of the trial,23 patients(38.33%)recovered,25(41.67%)improved notably,7(11.67%)improved.The excellence rate was 80.00%,and total effective rate was 91.67%.The rate of side effects was 46.67%.No severe side reactions occurred.Conclusion Ziprasidone could have good therapeutic effect and tolerance for treating patients with schizophrenia.

Key concepts: Ziprasidone, Schizophrenia (object-oriented programming), Clinical Global Impression, Positive and Negative Syndrome Scale, Internal medicine, Side effect (computer science), Psychopathology, Medicine

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