2002•Zhongguo linchuang yaolixue yu zhiliaoxueRequires access
Effects of propofol against myocardial MDA metabolism and water content after ischemia/reperfusion injury in isolated rat hearts
Jia Dong
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Abstract
AIM: To investigate the effect of propofol on myocardial malondialdehyde (MDA) metabolism and water content after ischemia/reperfusion injury in isolated rat heart with the modified Langredorff model. METHODS: Twenty four rats were randomly divided into four groups. Rat hearts were perfused with Krebs Henseleik(K H)in normal control group. In other three groups,a three phase protocal was performed: (1) 15-30 min preperfusion, (2) 20 min global normothermic(37 ℃)ischemia,and (3) 30 min reperfusion. Then the group P was treated with 30 μmol·L -1 propofol, the group P+G 30 μmol·L -1 propofol+10 μmol·L -1 glibenclamide before ischemia and throughout the experiment. Only K H buffer was perfused in the group I R. The content of water and MDA in myocardium and creatin kinase (CK) in the coronary effluent were measured. RESULTS: The recovery of hearts treated with propofol were better than that of group I R, indicated by lower content of water, MDA and CK level (P 0.01 ). No statistically significant differences were observed between group P and group P+G (P 0.05 ). CONCLUSION: Propofol can relieve myocardial edema by scavenging oxygen free radical and the mechanism is related to open of KATP channels.