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CFD Simulation of Mixing Process in Stirred Bioreactor and Its Application in Fermentation

Siliang Zhang

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Abstract

With the method of computational fluid dynamics(CFD),flow patterns,mixing time in a 50 L bioreactor equipped with multiple impellers were studied at different impeller combinations,and the best impeller combination was obtained.The best impeller combination from simulation was applied to the pyruvate oxidase produced by fermentation of recombinant E.coli.Results showed that this impeller combination had a better impact on the velocity field and distribution of oxygen.Rotation speed and maximal gas rate to attain specified dissolved oxygen concentration were reduced.Furthermore,the enzyme production and biomass were also increased slightly.

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What this paper is about

With the method of computational fluid dynamics(CFD),flow patterns,mixing time in a 50 L bioreactor equipped with multiple impellers were studied at different impeller combinations,and the best impeller combination was obtained.The best impeller combination from simulation was applied to the pyruvate oxidase produced by fermentation of recombinant E.coli.Results showed that this impeller combination had a better impact on the velocity field and distribution of oxygen.Rotation speed and maximal gas rate to attain specified dissolved oxygen concentration were reduced.Furthermore,the enzyme production and biomass were also increased slightly.

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Available abstract

With the method of computational fluid dynamics(CFD),flow patterns,mixing time in a 50 L bioreactor equipped with multiple impellers were studied at different impeller combinations,and the best impeller combination was obtained.The best impeller combination from simulation was applied to the pyruvate oxidase produced by fermentation of recombinant E.coli.Results showed that this impeller combination had a better impact on the velocity field and distribution of oxygen.Rotation speed and maximal gas rate to attain specified dissolved oxygen concentration were reduced.Furthermore,the enzyme production and biomass were also increased slightly.

Key concepts: Impeller, Mixing (physics), Bioreactor, Computational fluid dynamics, Chemistry, Fermentation, Biomass (ecology), Rotational speed

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