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2010•Journal of Guangxi Academy of SciencesRequires access

Study of Interaction and Structure-Activity Relationships between Three Flavonoids and BSA

Zhu Shi-yi

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Abstract

The structure-activity relationship and interaction between three flavonoids including Morin(MOR),Quercetin(QUE) and Rutin(RUT) and BSA were observed by UV-visible spectra and fluorescence quenching spectra.The results showed that the quenching and binding effect between flavonoids and BSA were strong when the.hydroxyl group was in the adjacent position of B benzene ring of nucleus.However,the quenching and binding effect between flavonoids and BSA decreased when a large group existed,which is due to the steric hindrances.

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What this paper is about

The structure-activity relationship and interaction between three flavonoids including Morin(MOR),Quercetin(QUE) and Rutin(RUT) and BSA were observed by UV-visible spectra and fluorescence quenching spectra.The results showed that the quenching and binding effect between flavonoids and BSA were strong when the.hydroxyl group was in the adjacent position of B benzene ring of nucleus.However,the quenching and binding effect between flavonoids and BSA decreased when a large group existed,which is due to the steric hindrances.

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Available abstract

The structure-activity relationship and interaction between three flavonoids including Morin(MOR),Quercetin(QUE) and Rutin(RUT) and BSA were observed by UV-visible spectra and fluorescence quenching spectra.The results showed that the quenching and binding effect between flavonoids and BSA were strong when the.hydroxyl group was in the adjacent position of B benzene ring of nucleus.However,the quenching and binding effect between flavonoids and BSA decreased when a large group existed,which is due to the steric hindrances.

Key concepts: Rutin, Chemistry, Quercetin, Steric effects, Morin, Quenching (fluorescence), Benzene, Flavonoid

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