Effect of Thrombolysis and Anticoagulation in the Treatment of Acute Submassive Pulmonary Thromboembolism

Objective To research the efficacy of thrombolysis and anticoagulation in the treatment of acute submassive pulmonary thromboembolism.Methods 24 patients with acute submassive pulmonary thromboembolism from March 2008 to December 2012 in our hospital were retrospectively analyzed.According to the different treatment programs,patients were divided into pure anticoagulant group and thrombolysis combined with anticoagulant group.Two groups of patients were routinely given general handling after admission,the pure anticoagulant group of 10 patients refused thrombolysis,so were given anticoagulant therapy alone; The thrombolysis combined with anticoagulant group of 14 patients agreed to thrombolysis,so were given thrombolysis combined anticoagulant therapy,they were treated for 10d.The PaO2and 6min walking distance of two groups were detected before and after treatment,and the occurrence of clinical manifestation of two groups were compared before and after treatment.Results After treatment,the PaO2and 6min walking distance of thrombolysis combined with anticoagulant group were higher than those of pure anticoagulant group,the incidence of difficulty breathing,chest pain,fever of thrombolysis combined with anticoagulant group was lower than that of pure anticoagulant group(P0.05).All of the patients did not appeared any hemorrhage of important position.Conclusion Compared with pure anticoagulation therapy,thrombolysis combined with anticoagulant therapy can better improve the patients' blood oxygen concentration and heart function and clinical symptom,and do not increase the risk of hemorrhage.