The oral acute and accumulative toxicity of 1,8-cineole on mice

The oral acute toxicity of 1,8- cineole on mice was tested by the modified Karber method,and the oral accumulative toxicity was carried out by a fixed dose method.The results showed that the half-lethal dose( LD50) of1,8-cineole was 3847.34 mg /kg.bw with the 95% confidence interval of 3352.80 ~ 4414.82mg /kg.bw. The liver and kidney were the key targets organ of acute poisoning of 1,8- cineole on mice. The accumulative toxicity test revealed that the accumulative coefficient K was larger than 5.No obviously influence of 1,8- cineole on the feed conversion rate and organ coefficient of mice was observed compared to the control group( p 0.05).1,8-cineole exhibited no obviously harmful effects on organ of mice.1,8-cineole displayed low acute toxicity and no obviously accumulative toxicity.