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2002•The Practical Journal of CancerRequires access

Expression of P-gp、GST-π and TopoII and its Clinical Significance in Gastric Carcinoma

Yi Zheng

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Abstract

Objective To study the clinical significance of P glycoprotein(P gp),glutathione S transferases(GST π) and DNA topoisomerase(TopoⅡ) expression in gastric carcinoma tissue.Methods The expressions of P gp?GST π and TopoⅡ in 125 cases of gastric carcinoma were detecd by S P immunohistochemical technique,its correlation to clinical pathologic characteristic of gastric carcinoma was explored.Results Positive expression of P gp?GST π and TopoⅡ were 56.8%?62.4% and 86.4% in cases of gastric carcinoma.The expressions of P gp?GST π and TopoⅡ were not found to correlate with patient′s age,sex,tumor size,tumor location,invased layer,differentiated degree,lymph node metastasis.Conclusion The determination of P gp?GST π and TopoⅡ may be useful for the establishment of chemical theraphy regimen in gastric carcinoma.

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Objective To study the clinical significance of P glycoprotein(P gp),glutathione S transferases(GST π) and DNA topoisomerase(TopoⅡ) expression in gastric carcinoma tissue.Methods The expressions of P gp?GST π and TopoⅡ in 125 cases of gastric carcinoma were detecd by S P immunohistochemical technique,its correlation to clinical pathologic characteristic of gastric carcinoma was explored.Results Positive expression of P gp?GST π and TopoⅡ were 56.8%?62.4% and 86.4% in cases of gastric carcinoma.The expressions of P gp?GST π and TopoⅡ were not found to correlate with patient′s age,sex,tumor size,tumor location,invased layer,differentiated degree,lymph node metastasis.Conclusion The determination of P gp?GST π and TopoⅡ may be useful for the establishment of chemical theraphy regimen in gastric carcinoma.

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Available abstract

Objective To study the clinical significance of P glycoprotein(P gp),glutathione S transferases(GST π) and DNA topoisomerase(TopoⅡ) expression in gastric carcinoma tissue.Methods The expressions of P gp?GST π and TopoⅡ in 125 cases of gastric carcinoma were detecd by S P immunohistochemical technique,its correlation to clinical pathologic characteristic of gastric carcinoma was explored.Results Positive expression of P gp?GST π and TopoⅡ were 56.8%?62.4% and 86.4% in cases of gastric carcinoma.The expressions of P gp?GST π and TopoⅡ were not found to correlate with patient′s age,sex,tumor size,tumor location,invased layer,differentiated degree,lymph node metastasis.Conclusion The determination of P gp?GST π and TopoⅡ may be useful for the establishment of chemical theraphy regimen in gastric carcinoma.

Key concepts: Topoisomerase, Gastric carcinoma, P-glycoprotein, Immunohistochemistry, Carcinoma, Lymph node metastasis, Clinical significance, Metastasis

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Expression of P-gp、GST-π and TopoII and its Clinical Significance in Gastric Carcinoma — Research Paper | ScholarLens