Diagnostic value of Dual-source CT perfusion imaging and serum makers in the evaluation stage of liver fibrosis

Objective To explore the value of evaluating the stage of liver fibrosis using dual-source CT perfusion paramaters and serum makers.Methods Intraperitoneal injection of CCl4 was used to induce liver fibrosis.46 rabbits in experimental group and 10 rabbits of control group were examined with dual-source CT perfusion imaging.Perfusion parameters including arterial liver perfusion(ALP),portal venous perfusion(PVP),hepatic perfusion index(HPI),blood flow(BF),blood volume(BV)along with serum fibrosis markers:hyaluronic(HA),laminin(LN),Procollagen typeⅢ(PCⅢ),Ⅳcollagen(Ⅳ-C)were achieved and compared with the different groups proved by pathology.All the perfusion parameters and serum makers were compared with the severity of fibrosis.Results PVP decreased as the increase of liver fibrosis.PVP between S0,S1 stage to S2,S3,S4 stage were significant different(P 0.05).The perfusion parameters as PVP and HPI showed little relationship with the severity of fibrosis(r=-0.84,P0.05;r=0.62,P0.05).The serum makers,especially HA,Ⅳ-C,was positively correlated with histopathological staging(P 0.05).Conclusion Dual-source CT perfusion and serum markers of fibrosis both have their own benefit and weakness in evaluating liver fibrosis degrees.Thus,combination two of them can improve the evaluation of liver fibrosis.