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2007•Acta Academiae Medicinae XuzhouRequires access

Hypertonia enhances expression of phosphotyrosine in supraoptic nucleus of rat

Youting Chen

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Abstract

Objective To study the effect of hypertonic stimulation on the expression of phosphotyrosine in supraoptic nucleus of rat.Methods The adult SD rats were divided into a test group and a control group(n=5 each)to receive intraperitoneal injection of hypertonic saline and normal saline respectively.The rats were infused with 4% paraformaldehyde 2 h after the injection,and then,the brains were removed to prepare 30 μm frozen sections.The expression of phosphotyrosine,as well as that of c-Fos,in the supraoptic nucleus was detected by immunohistochemistry.Results The expression of phosphotyrosine was higher in the hypertonic saline test group than in the control(P0.01).Conclusion Hypertonic stimulation enhances the expression of phosphotyrosine in supraoptic nucleus of rat.

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What this paper is about

Objective To study the effect of hypertonic stimulation on the expression of phosphotyrosine in supraoptic nucleus of rat.Methods The adult SD rats were divided into a test group and a control group(n=5 each)to receive intraperitoneal injection of hypertonic saline and normal saline respectively.The rats were infused with 4% paraformaldehyde 2 h after the injection,and then,the brains were removed to prepare 30 μm frozen sections.The expression of phosphotyrosine,as well as that of c-Fos,in the supraoptic nucleus was detected by immunohistochemistry.Results The expression of phosphotyrosine was higher in the hypertonic saline test group than in the control(P0.01).Conclusion Hypertonic stimulation enhances the expression of phosphotyrosine in supraoptic nucleus of rat.

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Available abstract

Objective To study the effect of hypertonic stimulation on the expression of phosphotyrosine in supraoptic nucleus of rat.Methods The adult SD rats were divided into a test group and a control group(n=5 each)to receive intraperitoneal injection of hypertonic saline and normal saline respectively.The rats were infused with 4% paraformaldehyde 2 h after the injection,and then,the brains were removed to prepare 30 μm frozen sections.The expression of phosphotyrosine,as well as that of c-Fos,in the supraoptic nucleus was detected by immunohistochemistry.Results The expression of phosphotyrosine was higher in the hypertonic saline test group than in the control(P0.01).Conclusion Hypertonic stimulation enhances the expression of phosphotyrosine in supraoptic nucleus of rat.

Key concepts: Supraoptic nucleus, Hypertonic saline, Paraformaldehyde, Tonicity, Stimulation, Hypertonia, Endocrinology, Internal medicine

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