Relationship between the serum biomarkers levels and the carotid artery plaque in atherosclerotic cerebral infarction patients

Objective To investigate the association of the levels of serum oxidized low density lipoprotein( ox- LDL),C- reactive protein( CRP) and matrix metalloproteinase- 9( MMP- 9) with carotid artery plaque in atherosclerotic cerebral infarction patients. Methods One hundred- ten patients with atherosclerotic cerebral infarction( ACI)selected as the observation group,and 100 healthy subjects as control group were selected to detect the level of serum ox- LDL,CRP and MMP- 9 by enzyme- linked immunosorbent assay and the ACI patients were measured by carotid artery ultrasound. Results The levels of serum ox- LDL,CRP,and MMP- 9 in observation group were higher than those in control group [( 261. 54 ± 24. 51) vs( 146. 51 ± 19. 59)μg·mL~(-1);( 4. 54 ±1. 21) vs( 0. 87 ±0. 15) μg·mL~(-1);( 139. 76 ±41. 22)vs( 65. 76 ± 23. 48) ng·mL~(-1),and there was significantly different( all P 0. 01). The levels of serum ox- LDL,CRP,and MMP- 9 in ACI patients with plaque were higher than those in ACI patients without plaque [( 205. 27 ± 20. 11) vs( 162. 50 ± 19. 71) μg·mL~(-1);( 4. 32 ±1. 03)vs( 1. 21 ± 0. 10) μg·mL~(-1);( 90. 71 ± 24. 03) vs( 71. 71 ± 23. 21) ng·mL~(-1),and there was significantly different( P 0. 01). Serum ox- LDL,CRP and MMP- 9 levels were the independent risk factors for the formation of carotid plaques of ACI patients,and had significantly positive correlation. Conclusion The high level of serum ox- LDL,CRP,and MMP- 9 are the independent risk factors for carotid plaques of ACI,which could be used as important reference indexes for diagnosis of the formation of carotid artery plaque on ACI patients.