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Effects of naloxne on hold-abilities and serum S100B protein of the intracerebral hemorrhage rats

Zhang You-cha

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Abstract

Objective To observe the effects of naloxne on hold-abilities and serum S100B protein of the intracerebral hemorrhage(ICH) rats. Methods Forty SD rats were randomly divided into sham-operation group(n=10), operation group(n=10), naloxne group(n=10) and piracetam group(n=10). The ICH model of rats was made according to Rosenberg method. Serum S100B protien was detected by ELISA method at 24 and 48 h and the hold-abilities of ICH rats were observed at the second day. Results Naloxne could significantly improve the hold-abilities of ICH rats as comparing with the operation group(P 0.05). The levels of serum S100B protein was significantly lower in naloxne group than that in operation group(P 0.05). Conclusion Naloxne can significantly improve the hold-abilities of ICH rats and decrease the levels of serum S100B protein, and then protect the intracerebral nerves from the injury induced by cerebral hemorrhage.

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Objective To observe the effects of naloxne on hold-abilities and serum S100B protein of the intracerebral hemorrhage(ICH) rats. Methods Forty SD rats were randomly divided into sham-operation group(n=10), operation group(n=10), naloxne group(n=10) and piracetam group(n=10). The ICH model of rats was made according to Rosenberg method. Serum S100B protien was detected by ELISA method at 24 and 48 h and the hold-abilities of ICH rats were observed at the second day. Results Naloxne could significantly improve the hold-abilities of ICH rats as comparing with the operation group(P 0.05). The levels of serum S100B protein was significantly lower in naloxne group than that in operation group(P 0.05). Conclusion Naloxne can significantly improve the hold-abilities of ICH rats and decrease the levels of serum S100B protein, and then protect the intracerebral nerves from the injury induced by cerebral hemorrhage.

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Available abstract

Objective To observe the effects of naloxne on hold-abilities and serum S100B protein of the intracerebral hemorrhage(ICH) rats. Methods Forty SD rats were randomly divided into sham-operation group(n=10), operation group(n=10), naloxne group(n=10) and piracetam group(n=10). The ICH model of rats was made according to Rosenberg method. Serum S100B protien was detected by ELISA method at 24 and 48 h and the hold-abilities of ICH rats were observed at the second day. Results Naloxne could significantly improve the hold-abilities of ICH rats as comparing with the operation group(P 0.05). The levels of serum S100B protein was significantly lower in naloxne group than that in operation group(P 0.05). Conclusion Naloxne can significantly improve the hold-abilities of ICH rats and decrease the levels of serum S100B protein, and then protect the intracerebral nerves from the injury induced by cerebral hemorrhage.

Key concepts: Intracerebral hemorrhage, Piracetam, Medicine, Normal group, Anesthesia, Rat model, Internal medicine, Gastroenterology

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