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2005•Journal of Clinical Emergency CallRequires access

Effects of Inflammatory Factors and Intercellular Adhesion Molecule-1(ICMA-1)on Hepatic Damage Induced by Endotoxin

Shusheng Li

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Abstract

Objective To observe the effects of inflammatory factors and intercellular adhesion molecule-1(ICAM-1) on hepatic dam- age induced by endotoxin.Methods Wistar rats were randomly divided into 2 groups:①sham operated control(S,n=8);②lipopolysac- charide(LPS n=8).The serum tumor necrosis factor α(TNF-α) and IL-6 levels in each group were measured.The immunohistochemistry was used to assess the expression of the ICAM-1 on the hepatic tissue.The pathologic lesions of hepatic tissues were observed.Results The levels of TNF-α and IL-6 in serum in LPS group are higher than those in sham operated control group (P0.01).The expression of ICAM- 1 in hepatic tissues were upregulated.The pathologic lesions of hepatic tissues were more serious than those in S group.Conclusion TNF-α and IL-6 in serum and ICAM-1 play an important role in causing of hepatic damage induced by endotoxin.

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What this paper is about

Objective To observe the effects of inflammatory factors and intercellular adhesion molecule-1(ICAM-1) on hepatic dam- age induced by endotoxin.Methods Wistar rats were randomly divided into 2 groups:①sham operated control(S,n=8);②lipopolysac- charide(LPS n=8).The serum tumor necrosis factor α(TNF-α) and IL-6 levels in each group were measured.The immunohistochemistry was used to assess the expression of the ICAM-1 on the hepatic tissue.The pathologic lesions of hepatic tissues were observed.Results The levels of TNF-α and IL-6 in serum in LPS group are higher than those in sham operated control group (P0.01).The expression of ICAM- 1 in hepatic tissues were upregulated.The pathologic lesions of hepatic tissues were more serious than those in S group.Conclusion TNF-α and IL-6 in serum and ICAM-1 play an important role in causing of hepatic damage induced by endotoxin.

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Available abstract

Objective To observe the effects of inflammatory factors and intercellular adhesion molecule-1(ICAM-1) on hepatic dam- age induced by endotoxin.Methods Wistar rats were randomly divided into 2 groups:①sham operated control(S,n=8);②lipopolysac- charide(LPS n=8).The serum tumor necrosis factor α(TNF-α) and IL-6 levels in each group were measured.The immunohistochemistry was used to assess the expression of the ICAM-1 on the hepatic tissue.The pathologic lesions of hepatic tissues were observed.Results The levels of TNF-α and IL-6 in serum in LPS group are higher than those in sham operated control group (P0.01).The expression of ICAM- 1 in hepatic tissues were upregulated.The pathologic lesions of hepatic tissues were more serious than those in S group.Conclusion TNF-α and IL-6 in serum and ICAM-1 play an important role in causing of hepatic damage induced by endotoxin.

Key concepts: Medicine, Tumor necrosis factor alpha, Intercellular Adhesion Molecule-1, ICAM-1, Immunohistochemistry, Pathology, Cell adhesion molecule, Adhesion

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Effects of Inflammatory Factors and Intercellular Adhesion Molecule-1(ICMA-1)on Hepatic Damage Induced by Endotoxin — Research Paper | ScholarLens