A comparison of the ocular hypotensive efficacy of three prostaglandin analogs

Objective To compare the ocular hypotensive efficacy of latanoprost,travoprost and bimatoprost.Methods Patients with primary open angle glaucoma(POAG) or ocular hypertension(OHT) were selected for the study.Fifty-one patients were treated once daily with latanoprost,24 patients were treated with travoprost and 27 patients were treated with bimatoprost for 4 weeks.Intraocular pressure(IOP) before and after the treatments was observed.Results The IOPs of all patients in the 3 groups had decreased markedly after 4 weeks.The daily average IOP(mean±standard deviation) at 8:30 in the latanoprost group decreased from(24.57±3.68)mmHg(1 mmHg=0.133 kPa) to (15.29±2.67)mmHg, and the maximum extent of the decrease was 37.8%;IOP in the travoprost group decreased from(24.54±2.95)mmHg to (16.29±3.11)mmHg,with a maximum decrease of 33.6%;and the reduction in the bimatoprost group was from(25.41±3.63)mmHg to(16.00±4.45)mmHg,with a maximum decrease of 37.0%.The effectiveness of the treatments did not differ significantly(F=0.579,P=0.562;F=0.868,P=0.423) when the three groups were compared.Conclusion This study demonstrated that latanoprost,travoprost and bimatoprost are all effective and lasting in reducing IOP in POAG and OHT.The 3 treatments do not differ significantly in their effectiveness.