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Characterization of macrolide resistance of Streptococcus pneumoniae from clinical isolates

Longhua Hu

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Abstract

Objective To understand the mechanisms of macrolide resistance and resistant phenotypes of Streptococcus pneumoniae in Nanchang . Methods Antibiotic susceptibilities were determined by the E-test method or K-B disk diffusion test according to Clinical Laboratory Standards Institute (CLSI). Macrolide resistant phenotypes were classified using a double disc test with erythromycin and clindamycin discs (Dtest). Results Of 84 isolates, 85.7% (72/84) was resistant to erythromycin, with 57.1% (48/84) of PNSSP. Amoxicillin/clavacin and levofloxacin retained activities against the most of the isolates. Conclusions The most strains in our data are highly resistant to erythromycin, and the most common macrolide resistance phenotype is the cMLSB phenotype in Nanchang.

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What this paper is about

Objective To understand the mechanisms of macrolide resistance and resistant phenotypes of Streptococcus pneumoniae in Nanchang . Methods Antibiotic susceptibilities were determined by the E-test method or K-B disk diffusion test according to Clinical Laboratory Standards Institute (CLSI). Macrolide resistant phenotypes were classified using a double disc test with erythromycin and clindamycin discs (Dtest). Results Of 84 isolates, 85.7% (72/84) was resistant to erythromycin, with 57.1% (48/84) of PNSSP. Amoxicillin/clavacin and levofloxacin retained activities against the most of the isolates. Conclusions The most strains in our data are highly resistant to erythromycin, and the most common macrolide resistance phenotype is the cMLSB phenotype in Nanchang.

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Available abstract

Objective To understand the mechanisms of macrolide resistance and resistant phenotypes of Streptococcus pneumoniae in Nanchang . Methods Antibiotic susceptibilities were determined by the E-test method or K-B disk diffusion test according to Clinical Laboratory Standards Institute (CLSI). Macrolide resistant phenotypes were classified using a double disc test with erythromycin and clindamycin discs (Dtest). Results Of 84 isolates, 85.7% (72/84) was resistant to erythromycin, with 57.1% (48/84) of PNSSP. Amoxicillin/clavacin and levofloxacin retained activities against the most of the isolates. Conclusions The most strains in our data are highly resistant to erythromycin, and the most common macrolide resistance phenotype is the cMLSB phenotype in Nanchang.

Key concepts: Erythromycin, Levofloxacin, Microbiology, Clindamycin, Macrolide Antibiotics, Streptococcus pneumoniae, Phenotype, Amoxicillin

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