Effect of asphyxia on newborn hyperbilirubinaemia

Objective To explore the effect of asphyxia in neonatal hyperbilirubinaemia.Methods Serum bilirubin was measured in 154 full-term neonates with asphyxia and in 87 normal neonates of 1 or 2 or 3 days of age, after the discovery of jaundice. Results The levels of bilirubin on 1, 2. 3days of age in neonates with mild asphyxia were (49. 7± 11.1)μmol/L, (84. 6 ±13.8) μmol/L, (152. 6±15. 3)μmol/L and severe asphyxia (64.3±12.2) μmol/L, (108. 3±13.3) μmol/L and (130. 2±14.2) μmol/L, which were signifacant lower than that in normal neonates. The levels of bilirubin on 1, 2 days of age in neonates with severe asphyxia were signifacant higher than that in neonates with mild asphyxia. The level of bilirubin on 3 day of age was signifacant lower than that in neonates with mild asphyxia. The rate of hyperbilirubinaemia in 154 cases was 13.7 % (21/154). Mild asphyxia was 13- 7 % (14/102) and severe asphyxia was 13.5 % (7/52). The duration of the occurrence of hyperbilirubinaemia in neonates with mild asphyxia was shorter than that of neonates with severe asphyxia . The duration of jaundice was longer than that of neonates with severe asphyxia. The duration of the occurrence of peak value was shorter than that of neonates with severe asphxia and the peak value of bilirubin (328. 3±18. 3 μmol/L) was higher than that of neonates with severe asphyxia (306. 1±15.4)μmol/L. Conclusion The rate of hyperbilirubinaemia in full-term neonates with asphyxia is low. The degree of hyperbilirubin-aemia is not in line with the degree of asphyxia. Pay attention to the dual nature of bilirubin when hyperbihrubinaemia in full-term neonates with asphyxia is beening predicated.