Clinical research of YiShenJuanBi Capsules in the Treatment of Rheumatoid Arthritis

Objective:To observe and appraise the efficacy and Safety of YiShenJuanBi capsules in the treatment of rheumatoid arthritis.Methods:439 patients(renal spleen deficiency and cold dampness Stagnation syndrome) with rheumatoid arthritis were treated,in which 329 patients used the YiShenJuanBi capsules(as therapeutic group)and the others used Tongbi capsules and placebo(as control group),they were treated with capsules respectively,2 each time(Tongbi capsules contains 3 capsules of simulative preparations),3 times a day,and for 2 months.Calculating rate of improvement in major symptoms and Signs,improvement of ESR and CRP,evaluated the efficacy before and after treatment fortnightly.During these periods,probing the improvement 0f TCM clinical symptoms and integral Syndrome judged the TCM efficacy.Meanwhile,carring out security examination such as three routines,functions of heart,liver and kidney,semen and spleen observed the change of the security index.Results:After the treatment,the two groups both were obviously improved the symptoms and signs.The efficiency of therapeutic group was 86.7% in the efficacy and 87.3% in the TCM efficacy.The total TCM clinical symptoms and integral Syndrome were dramaticaly improved,and there was significant difference between therapeutic group and control group.No Adverse Reactions had been found in our therapeutic group.Conclusion:YiShenJuanBi capsules has the effect of promoting qi to activate blood and activating meridians to stop pain in our research.It is an ideal medicine in treating the rheumatoid arthritis that is caused by renal spleen deficiency and cold dampness Stagnation.