2005•Zhongguo linchuang yaolixue yu zhiliaoxueRequires access
Study of Salvia miltiorrhiza on bleomycin-induced pulmonary fibrosis in mice
Wang Hua-zhou
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Abstract
AIM: To study protective effects of Salvia miltiorrhiza on bleomycin (BLM)-induced pulmonary fibrosis in mice. METHODS: Animal model with pulmonary fibrosis in SD mice was replicated by intratracheal injections of bleomycin and Salvia miltiorrhiza injection were given after replicated 7th day. Rats were executed in 7th and 28th day, MDA, GSH and HYP in lung tissue bomogenate and the lung histopathological change were detected to investigate the effects of Salvia miltiorrhiza injection on lung fibrisis form in different stages. RESULTS: Salviae miltiorrhizae injection given after replicated first day restrained the increase of MDA and HYP, and decreased the GSH of lung tissue bomogenate, and lighten pathological lesion. Salvia miltiorrhiza injection given after replicated the 7th day had no statistical difference between Salvia miltiorrhiza therapy groups and model group. CONCLUSION: Salvia miltiorrhiza injection can prevent mice pulmonary fibrosis from and has no side effects on formative rat pulmonary fibrosis.