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2007•Chinese Clinical OncologyRequires access

Clinical study of advanced gastric cancer patients treated with leucovorin,5-fluorouracil and oxaliplatin(FOLFOX4)chemotherapy

Yuan Min

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Abstract

Objective:To evaluate the efficacy and adverse effects of oxaliplatin combined with 5-fiuorouracil(5-FU)and calcium folinate in the treatment of patients with advanced gastric cancer.Methods:Twenty eight patients with advanced gastric cancer received chemotherapy of regimen L-OHP 85mg/m2 2 hours d1,CF 200mg/m2 2 hours d1,d2,followed by 5-FU 400mg/m2 iv and 600mg/m2 22 hours civ d1,d2,two weeks as one cycle.Efficacy was evaluated after 4 cycles.Results:Two patients achieved complete response(CR),14 patients partial response(PR),7 patients stable disease(SD),5 patients progression disease(PD).Overall response rate was 57.1%.The major toxicity included nausea,vomiting,leucopenia and neurosensory.Conclusion:This study shows that the regimen of FOLFOX4 is effective and tolerable in advanced gastric cancer.

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Objective:To evaluate the efficacy and adverse effects of oxaliplatin combined with 5-fiuorouracil(5-FU)and calcium folinate in the treatment of patients with advanced gastric cancer.Methods:Twenty eight patients with advanced gastric cancer received chemotherapy of regimen L-OHP 85mg/m2 2 hours d1,CF 200mg/m2 2 hours d1,d2,followed by 5-FU 400mg/m2 iv and 600mg/m2 22 hours civ d1,d2,two weeks as one cycle.Efficacy was evaluated after 4 cycles.Results:Two patients achieved complete response(CR),14 patients partial response(PR),7 patients stable disease(SD),5 patients progression disease(PD).Overall response rate was 57.1%.The major toxicity included nausea,vomiting,leucopenia and neurosensory.Conclusion:This study shows that the regimen of FOLFOX4 is effective and tolerable in advanced gastric cancer.

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Available abstract

Objective:To evaluate the efficacy and adverse effects of oxaliplatin combined with 5-fiuorouracil(5-FU)and calcium folinate in the treatment of patients with advanced gastric cancer.Methods:Twenty eight patients with advanced gastric cancer received chemotherapy of regimen L-OHP 85mg/m2 2 hours d1,CF 200mg/m2 2 hours d1,d2,followed by 5-FU 400mg/m2 iv and 600mg/m2 22 hours civ d1,d2,two weeks as one cycle.Efficacy was evaluated after 4 cycles.Results:Two patients achieved complete response(CR),14 patients partial response(PR),7 patients stable disease(SD),5 patients progression disease(PD).Overall response rate was 57.1%.The major toxicity included nausea,vomiting,leucopenia and neurosensory.Conclusion:This study shows that the regimen of FOLFOX4 is effective and tolerable in advanced gastric cancer.

Key concepts: Oxaliplatin, Medicine, Nausea, Vomiting, Regimen, Fluorouracil, Internal medicine, Gastroenterology

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Clinical study of advanced gastric cancer patients treated with leucovorin,5-fluorouracil and oxaliplatin(FOLFOX4)chemotherapy — Research Paper | ScholarLens