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2003•Chinese Journal of Industrial MedicineRequires access

The assay of CYP2E1 activity in biological system

Wang Ai

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Abstract

Cytochrome P450(CYP)is one of the main hepatic metabolic enzymes of phase I.Cytochrome P450 2E1,one member of CYP family,plays a significant role in the metabolism activation of chemicals,and its activity is strongly related to the final toxicity of chemicals.In the past years,many experts have put much endeavor to tackle this troublesome problem.This paper reviewed the progress of CYP2E1 activity assay in recent years.

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What this paper is about

Cytochrome P450(CYP)is one of the main hepatic metabolic enzymes of phase I.Cytochrome P450 2E1,one member of CYP family,plays a significant role in the metabolism activation of chemicals,and its activity is strongly related to the final toxicity of chemicals.In the past years,many experts have put much endeavor to tackle this troublesome problem.This paper reviewed the progress of CYP2E1 activity assay in recent years.

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Available abstract

Cytochrome P450(CYP)is one of the main hepatic metabolic enzymes of phase I.Cytochrome P450 2E1,one member of CYP family,plays a significant role in the metabolism activation of chemicals,and its activity is strongly related to the final toxicity of chemicals.In the past years,many experts have put much endeavor to tackle this troublesome problem.This paper reviewed the progress of CYP2E1 activity assay in recent years.

Key concepts: CYP2E1, Cytochrome P450, Chemistry, Cytochrome, Toxicity, CYP2D6, Drug metabolism, Enzyme

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