The outcome and mechanism of CPR priority in a porcine model of prolonged ventricular fibrillation

Objective To compare the efficacy and mechanism of CPR first or shock first on the outcome of 7-minute ventricular fibrillation.Methods The ventricular fibrillation was electrically induced in a porcine model.After two minutes of CPR was performed,first preceding of non-stop three times defibrillation in CPR First groups While defibrillation was deliveried up to three times shocks in Shock First groups.If VF was no reversed after three times shocks,CPR was started for 1 minute.The rate of compression vs ventilation was 30∶2.The change of Coronary perfusion pressure,the VF's frequency and amplitude were measured.The rate of successful defibrillation and return of spontaneous circulation were recorded.Results Precounter shock cardiopulmonary resuscitation improved response to defibrillation from 7 minutes prolonged VF.Conclusion CPR priority improved the outcome of the prolonged ventricular fibrillation,the mechanism of which related improving coronary perfusion and increasing VF's frequency and amplitude.