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2008•Journal of clinical and experimental medicineRequires access

The immediate response of chemotherapy combined with radiotherapy in treatment of advanced nasopharyngeal carcinoma

Hong-Yan Qiu

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Abstract

Objective To study the immediate response and toxic side effects of patients with nasopharyngeal carcinoma treated by radiotherapy(RT)combined with chemotherapy(CT).Methods Seventy-three cases of medium or advanced nasopharyngeal carcinoma were studied,43 of them were treated by chemotherapy followed with radiotherapy,and the remaining 30 cases were only treated by radiotherapy.Chemotherapy was consisted of 5-FU 0.5/m2 in days 1-5 plus DDP 20mg/m2 in days 1～4 by intravenous infusion.Results All cases had followed-up for 5 years.The 3 and 5 year survival rates of(CT+RT)group and RT group were 62.8%,56.7% and51.2%,46.7%respectively(P0.05).The distant metastasis rates were 46.5%in(CT+RT)group and 60% in(RT)group respectively(P0.05).There were no untolerable toxic and side effects.Conclusion CT plus RT may reduce the rate of distant metastasis and untolerable toxic and side effects.

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Objective To study the immediate response and toxic side effects of patients with nasopharyngeal carcinoma treated by radiotherapy(RT)combined with chemotherapy(CT).Methods Seventy-three cases of medium or advanced nasopharyngeal carcinoma were studied,43 of them were treated by chemotherapy followed with radiotherapy,and the remaining 30 cases were only treated by radiotherapy.Chemotherapy was consisted of 5-FU 0.5/m2 in days 1-5 plus DDP 20mg/m2 in days 1～4 by intravenous infusion.Results All cases had followed-up for 5 years.The 3 and 5 year survival rates of(CT+RT)group and RT group were 62.8%,56.7% and51.2%,46.7%respectively(P0.05).The distant metastasis rates were 46.5%in(CT+RT)group and 60% in(RT)group respectively(P0.05).There were no untolerable toxic and side effects.Conclusion CT plus RT may reduce the rate of distant metastasis and untolerable toxic and side effects.

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Available abstract

Objective To study the immediate response and toxic side effects of patients with nasopharyngeal carcinoma treated by radiotherapy(RT)combined with chemotherapy(CT).Methods Seventy-three cases of medium or advanced nasopharyngeal carcinoma were studied,43 of them were treated by chemotherapy followed with radiotherapy,and the remaining 30 cases were only treated by radiotherapy.Chemotherapy was consisted of 5-FU 0.5/m2 in days 1-5 plus DDP 20mg/m2 in days 1～4 by intravenous infusion.Results All cases had followed-up for 5 years.The 3 and 5 year survival rates of(CT+RT)group and RT group were 62.8%,56.7% and51.2%,46.7%respectively(P0.05).The distant metastasis rates were 46.5%in(CT+RT)group and 60% in(RT)group respectively(P0.05).There were no untolerable toxic and side effects.Conclusion CT plus RT may reduce the rate of distant metastasis and untolerable toxic and side effects.

Key concepts: Medicine, Nasopharyngeal carcinoma, Radiation therapy, Chemotherapy, Distant metastasis, Metastasis, Internal medicine, Carcinoma

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