The Effect of Herceptin on Nasopharyngeal Carcinoma Cells Line Growth in Vivo and in Vitro

Objective To study the effect of Herceptin on nasopharyngeal carcinoma (NPC) cells line growth in vivo and vitro. Methods Immounhistochemical assay was used to detect HER-2/neu gene expression in NPC specimens;the effect of Herceptin on NPC cells line growth were tested by ~3H-TdR incorporation in vivo and by model of xenografts tumor nude mice in vitro. Results HER-2/neu gene overexpression was detected in NPC tissues; the ~3H-TdR incorporation of a NPC cells line CNE-2Z overexpressed HER-2/neu gene was inhibited by Herceptin and Herceptin had the effect of tumor growth on xenografts tumor nude mice. Conclusion The ~3H-TdR incorporation of NPC cells line CNE-2Z was inhibited in vitro and the growth of CNE-2Z had been affected in vivo by Herceptin.