Cytokeratin 19 Fragment K19-2G2 Detection in Lung Cancer

[Purpose] To investigate the clinical significance of cytokeratin 19 fragment K19-2G2 detection in lung cancer.[Methods] K19-2G2 and CYFRA21-1 in 345 cases with lung cancer,150 cases with lung benign disease and 500 health volunteers(control group) were detected by chemiluminoimmunoassay and electrochemiluminescence methods.[Results] The serum content of K19-2G2 and CYFRA21-1 was significantly elevated in patients with lung cancer compared those with lung benign diseases(P0.01) or normal control group(P0.01).The sensitivity and specificity of K19-2G2 detection in lung cancer were 61.45% and 97.69% respectively,with significantly higher than those of CYFRA21-1(P0.05).The serum content of K19-2G2 and CYFRA21-1 in non-small cell lung cancer was significantly higher than those in small cell lung cancer(P0.05).The serum content and positive rate of K19-2G2 in patients with early stage non-small cell lung cancer were similar to those in advanced non-small cell lung cancer.[Conclusion] K19-2G2 is sensitive and specific to lung cancer diagnosis,especially in non-small cell lung cancer.It is helpful to diagnose for non-small cell lung cancer in early stage.