INFLUENCE OF IL-10 ON TREATMENT AND PROGNOSIS OF ACUTE CEREBRAL INFARCTION

[Objective]To observe the change of IL-10 in serum of acute cerebral infarction patients and study its effect on the secondary brain injury.[Methods]The IL-10 level of 60 cerebral infarction patients were detected with ELISA 24 h,3 days and 7 days after onset,infarct size and peripheral blood leucocyte content were determined within 24 h.[Results]IL-10 level in serum of acute cerebral infarction patients was higher than that in the control group at 24 h,3 days,7 days after onset(P﹤0.01). It obviously rised at 24 h, reached peak at the third day,then descended gradually,but it was still higher than that in the control group at the seventh day(P﹤0.05). In addition,the IL-10 level of the patients with large area infarction was higher than that of the patients with smaller area. Furthermore,the peripherat blood leucocyte level of acute cerebral Infarction patients was higher than that in the control group(P﹤0.05). Acute cerebral Infarction developed brain injury might lead to the increase expression of IL-10'. IL-10 possessed neuroprotective effect which profited neuro repair and survival after ischemic damnification.[Conclusion]The change of level of IL-10 is related to the process of cerebral ischemia and the size of ischemia. Whether we can treat cerebral infarction and alleviate cerebral damage with IL-10 needs further study.