Effects of azelaic acid and tretinoin cream in the treatment of facial post-burn hyperpigmentation

Objective:To investigate the method for treating facial post-burn hyperpigmentation. Methods: Forty-two patients with facial post-burn hyperpigmentation were randomly divided into two groups.Twenty-four subjects applied 15% Azelaic Acid cream combined with 0.025% Tretinoin cream daily to face,and eighteen subjects applied vehicle cream.At base line and six weeks of treatment,each subject's facial hyperpigmentation was assessed by area and colorimetric evaluations.Results:The facial post-burn hyperpigmentation of the Azelaic Acid and Tretinoin-treated subjects were significantly lighter after six weeks of therapy than those of the vehicle-treated subjects(χ~(2)=10.94,P 0.01).Conclusion:Topical application of 15% Azelaic Acid cream combined with 0.025% Tretinoin cream is effective in treating facial post-burn hyperpigmentation.